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    In colorectal cancers there are three well-established pathways;Chromosomal Instability (CIN), Microsatellite Instability (MSI) and the CpG IslandMethylator Phenotype (CIMP), the latter being most closely related to cancers withMSI. However,these p-values can only be used to examine the effect within a specific agecategory, and it would have been more useful to show the overall p-valuefor age, which addresses the question of whether there is an associationper se between age and QoL among these patients (see Section ‘Interpretingp-values for factors that have ?3 levels’, page 76). The time to onset is highly variable, rangingfrom one day to years after exposure.

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